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KMID : 0614619930250040696
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Korean Journal of Gastroenterology
1993 Volume.25 No. 4 p.696 ~ p.710
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Effect of Common Bile Duct Ligation on Liver Cathepsins B, D, H and Acid Phosphatase Activities in Ethanol Intoxicated Rats
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Abstract
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The hepatic cathepsins B, D, H and acid phosphatase activities were studied in cholestasis induced by common bile duct (CBD) ligation and chronic ethanol intoxication and in cholestasis after acute ethanol intoxication to establixh the
biochemical
background of alcohol hazard in hepatobiliary disease. Cathepsin D activity in the rat's liver increased markedly when CBD was ligated after chronic ethanol intoxication and when acute ethanol intoxication was induced after CBD ligation. And the
extent
of icrease in these groups were more significant than that in the CBD ligation only groups.
Lysosomal and microsomal acid phosphatase activities in the rat's liver increased significantly when CBD was ligated after chronic ethanol intoxication. And the extent of increase in this groups was more significant than that in the CBC ligation
only
group. Cytosolic lysosomal and microsomal acid phosphatase activities in the rat's liver increased significantly when acute ethanol intoxication was induced after CBD ligation, and extent of increase in this group was more significant than that
in
the
CBD ligation only group. According to the results, when ethanol intoxication is combined with cholestasis, cathepsin D and acid phosphatase in the liver seem to be increase in their activites, and the causes of the increase are thought to be
increased
biosynthesis.
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